The Damage Control Strategy for the Treatment of Perforated Diverticulitis of the Sigmoid Colon With Diffuse Peritonitis - a Retrospective, Multicenter, Transnational Cohort Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

The best approach for the treatment of perforated diverticulitis of the sigmoid colon is still under debate. Concurrent techniques are 1) resection with primary colorectal anastomosis with or without additional loop ileostomy; 2) end colostomy (Hartmann´s procedure); 3) Damage control strategy; 4) laparoscopic lavage and placement of a drainage. It is hypothesized, that the use of the damage control strategy leads to a significant reduction of the stoma rate. The damage control strategy constitutes a two stage procedure. Emergency surgery: limited resection of the diseased colonic segment with oral and aboral blind closure, abdominal lavage, temporary vacuum assisted abdominal closure Second look surgery (48-72 hours later): Reexploration with 1. definite reconstruction (Colorectal anastomosis -/+ diverting ileostomy vs. end colostomy) 2. lavage, vacuum assisted abdominal closure, third look 72 hours after emergency surgery Within the study, data of DCS-procedures will be collected retrospectively in a multicentric and transnational approach. Those will be compared to a cohort of patients treated with a no-DCS-technique (resection with primary anastomosis or Hartmann´s procedure).

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• all patients who were operated for perforated diverticulitis with generalized peritonitis

Locations
Other Locations
Germany
Dr. Maximilian Sohn
RECRUITING
Munich
Time Frame
Start Date: 2020-11-01
Estimated Completion Date: 2024-06-01
Participants
Target number of participants: 600
Treatments
Study Group
All consecutive patients who underwent damage control surgery (DCS) for perforated diverticulitis of the sigmoid colon with generalized Peritonitis in one of the participating centers
Control group
All consecutive patients who underwent other than DCS surgery (resection with primary anastomosis, Hartmann´s procedure, laparoscopic lavage) for perforated diverticulitis of the sigmoid colon with generalized Peritonitis in one of the participating centers which do not apply DCS routinely.
Sponsors
Leads: Städtisches Klinikum München GmbH
Collaborators: Medical University Innsbruck, Charite University, Berlin, Germany, University of Pisa, Cardarelli Hospital

This content was sourced from clinicaltrials.gov