Bronchial Asthma and Diabetes: Impact on Bronchial Inflammation and Exercise Capacity
Type 2 diabetes is the most common form of diabetes and according to several studies, even lung can represent another target of the diabetic disease. Asthmatic patients often show comorbidities and obesity is one of the main.Several studies in literature suggest that patients with higher Body Mass Index (i.e. overweight and obese) have a greater risk of developing asthma compared to normal weight subjects. Considering inflammation, asthma is usually characterized by an increase of eosinophils in the airways and by a Th2 type inflammation, while a immunological type Th1 switch systemically characterizes diabetes. Even asthmatic patients, especially if diabetic, might have an increase of glucose in their airways, that could favourite or feed an inflammatory/infective state. Up to-day there are not in literature studies that have investigated the airways inflammatory pattern and the exercise capacity in relation to functional characteristics in diabetic patients affected by asthma.
• Diagnosis of bronchial asthma according to the GINA 2018 guideline
• Clinical stability of asthmatic disease
• Diagnosis of Type II diabetes according to the last Italian guidelines (1) and HbA1c \< 9%, 54-75mmol/mol
• Concomitant diagnosis of bronchial asthma (12) and diabetes according to the described guidelines
• Age ≥18 years
• Not-smokers, smokers or ex-smokers with pack/year ≤10
• Patients able to collaborate in the required procedures and who have signed the informed consent