Mechanisms and Outcomes in Patients With Arrhythmic Mitral Valve Prolapse Undergoing Mitral Valve Surgery

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Study objectives: * To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP Study design: -Prospective explorative observational study Study population: -90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age 18 and over

• Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care

Locations
Other Locations
Sweden
Karolinska Univeristy Hospital
RECRUITING
Stockholm
Time Frame
Start Date: 2024-02-21
Estimated Completion Date: 2026-03-01
Participants
Target number of participants: 90
Treatments
Arrhythmogenic mitral valve prolapse versus non-arrhythmogenic mitral valve prolapse
Surgical repair or replacement of the mitral valve due to significant mitral regurgitation according to standard of care.
Sponsors
Collaborators: Karolinska University Hospital
Leads: Karolinska Institutet

This content was sourced from clinicaltrials.gov

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