Natural History of Severe Allergic Inflammation and Reactions
Background: - Allergic inflammation is central to allergy-related diseases and disorders, such as asthma, food allergies, and atopic dermatitis. Atopic dermatitis, commonly called eczema is a chronic, noncontagious skin condition, usually starting in the first years of life, which causes itching and scaling of an individual s skin. Because atopic dermatitis is a common condition in children who have allergy-related diseases, including asthma, researchers are interested in studying both individuals with atopic dermatitis and their close relatives (parents and children) to better understand how allergy-related diseases develop and progress. In addition, some patients with inherited disorders with features including atopic dermatitis or other aspects of allergy such as food allergy, asthma, hay fever, hives, and others, will also be seen.
Objectives: - To study the natural history of diseases of allergic inflammation, such as atopic dermatitis or genetic disorders associated with allergic inflammation.
Eligibility: * Children and adolescents between 1 month and 21 years of age who have a documented history of moderate to severe atopic dermatitis. * Individuals between 1 month and 80 years of age who have a suspected genetic or inherited allergy disorder related to atopic dermatitis or allergic pathways. * Child and adult relatives of eligible participants will also be studied on this protocol.
Design: * The study will require one initial visit to the National Institutes of Health Clinical Center (lasting 1-5 days), as well as any required follow-up visits for treatment and research studies. Participants will receive treatment for atopic dermatitis and other allergic diseases as part of the study for up to 1 year. * Participants will have some or all of the following tests as part of this study: * A detailed physical examination and medical history * Allergy skin prick testing to examine participants' responses to different allergens. * Blood samples for additional allergen testing, testing the immune system, and other research purposes * Skin punch biopsy to take a skin sample * Lung function tests to measure airflow from the lungs and inflammation * Food-related tests to diagnose potential food allergies * Leukapheresis to collect white blood cells only * Research samples, including stool specimens, saliva samples, buccal swabs (to collect cells from the inside of the cheek), and skin cell samples * Clinical digital photography to provide images of affected and healthy skin. * Participants will be asked to return for follow-up visits and tests for up to 1 year after the initial visit(s).
• Subject or unaffected relatives must:
‣ Be at least 2 years of age and less than or equal to 21 years of age at the time of enrollment and have documented history of severe allergic inflammation or hypersensitivity, that began in the first 5 years of life, that is moderate to severe, and with continued inflammation or
‣ recurrent flares in the preceding 3 months. Patients greater than 21 years of age with a history of disease in the first 5 years of life and/or, if in the opinion of the PI or AIs, the patient would be of interest to fulfill the objectives of the study.
‣ OR
⁃ Be 2-80 years of age with a known or suspected genetic or congenital disorder associated with severe allergic inflammation or
‣ hypersensitivity, as determined by the PI or AIs.
‣ OR
⁃ Be an a relative of a patient enrolled in the protocol.
• Have a private physician to provide local continuity of care.
• Provide a letter of referral, with copies of pertinent medical history and laboratory studies as indicated, from the prospective study participant s referring physician; this is not a requirement for healthy relatives.
• Be willing to donate blood, buccal swabs, saliva, skin and nasal swabs for research and clinical studies and for storage to be used for future research and genetic testing; for unaffected relatives, be willing to donate blood and/or undergo allergy skin testing, in addition to having blood samples stored for future research and genetic testing.
• Pregnant women or women who become pregnant are eligible to participate or continue participation on the study.
∙ Healthy Volunteer must:
• Be at least 18 years old and no greater than 80 years old, and able to provide informed consent.
‣ Have no history of severe or recurrent allergic diseases or reactions.
• Be willing to have samples stored for research and genetic testing.