Studies on chemical constituents in the buds of Tussilago farfara

Objective: To study the chemical constituents in the buds of Tussilago farfara.

Methods: The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by NMR and MS evidences.

Results: Eleven compounds were obtained and identified as methyl 3, 4-O-dicaffeoylquinate (1), methyl 3, 5-O-dicaffeoylquinate (2), methyl 4, 5-O-dicaffeoylquinate (3), 3, 5-O-dicaffeoylquinic acid (4), methyl 3-O-caffeoylquinate (5), 3-O-caffeoylquinic acid (6), hyperoside (7), rutin (8), kaempferol 3-O-beta-D-glucopyranoside (9), quercetin (10), and kaempferol (11).

Conclusions: Compounds 2-5 were isolated from the genus for the first time.