Early onset of ganciclovir-resistant cytomegalovirus infection in a lung-transplant recipient.

Journal: The Japanese Journal Of Thoracic And Cardiovascular Surgery : Official Publication Of The Japanese Association For Thoracic Surgery = Nihon Kyobu Geka Gakkai Zasshi
Published:
Abstract

Ganciclovir resistance in cytomegalovirus (CMV) is an increasing problem in lung-transplant recipients with adverse clinical outcomes. We experienced the successful treatment of ganciclovir-resistant CMV infection in a lung-transplant recipient still receiving CMV prophylaxis. A 24-year-old woman with lymphangioleiomyomatosis underwent a living-donor lobar lung transplantation. She was a primary CMV mismatch (D+/R-) patient. She recovered from her postoperative complications, and was about to be discharged. However, she suffered ganciclovir-resistant CMV infection during prophylactic therapy. She was successfully treated with foscarnet, and is now alive without recurrence 18 months after surgery.

Authors
Fengshi Chen, Toru Bando, Nobuharu Hanaoka, Tatsuo Fukuse, Seiki Hasegawa, Hiromi Wada