Failure to detect human herpes simplex virus, cytomegalovirus, and Epstein-Barr virus viral genomes in giant cell arteritis biopsy specimens by real-time quantitative polymerase chain reaction.

Journal: Cardiovascular Pathology : The Official Journal Of The Society For Cardiovascular Pathology

Published: March 24, 2006

Abstract

A study provided evidence of human herpes simplex virus (HSV) DNA in giant cell arteritis (GCA) biopsy specimens. This prompted us to study our own GCA biopsy specimens using real-time quantitative polymerase chain reaction for the detection of HSV1, cytomegalovirus, and Epstein-Barr virus DNAs. Our study failed to confirm an association between HSV1 and GCA, revealing no viral genome in 35 biopsy specimens of histologically positive temporal arteries.

Authors

Milena Cankovic, Richard Zarbo

Relevant Conditions

Temporal Arteritis, Mononucleosis, Vasculitis, Cytomegalovirus Infection, Giant Cell Arteritis (GCA), Cytomegalic Inclusion Disease, Juvenile Temporal Arteritis

Failure to detect human herpes simplex virus, cytomegalovirus, and Epstein-Barr virus viral genomes in giant cell arteritis biopsy specimens by real-time quantitative polymerase chain reaction.

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