Scanning laser polarimetry with enhanced corneal compensation and optical coherence tomography in normal and glaucomatous eyes.

Objective: To examine the association between scanning laser polarimetry (SLP), using enhanced (ECC) and variable corneal compensation (VCC) with optical coherence tomography (OCT), and to compare their discriminating ability in the diagnosis of glaucoma.

Methods: Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, SLP-VCC, and OCT. Eyes were characterized in two groups based on the typical scan score (TSS): Normal birefringence pattern (NBP) was defined as a TSS of 80 to 100 and abnormal birefringence pattern (ABP) as TSS

Results: Ninety-five normal volunteers and 63 patients with glaucoma were enrolled. Average visual field mean deviation was -4.2 +/- 4.3 dB in the glaucoma group. In eyes with NBP, SLP-ECC had significantly (all P

Conclusions: Compared with SLP-VCC, SLP-ECC has significantly stronger correlations with OCT and may improve the discriminating ability for early glaucoma diagnosis.