Copper-catalyzed Ficini [2 + 2] cycloaddition of ynamides.

Journal: Organic Letters
Published:
Abstract

The Ficini [2 + 2] cycloaddition using N-sulfonyl-substituted ynamides is described, featuring the utility of CuCl(2) and AgSbF(6) as catalysts. This work represents the first successful example of ynamides participating in a thermal [2 + 2] cycloaddition with enones.

Authors
Hongyan Li, Richard Hsung, Kyle Dekorver, Yonggang Wei