Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease.

Background: Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed.

Objective: To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease.

Methods: The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport was started in all six cases.

Results: Marked improvement of the lesions was achieved with few side effects in all patients.

Conclusions: Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.