Catalytic asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides using homogeneous chiral nickel-bisphosphine complexes through DKR.
Journal: Chemical Communications (Cambridge, England)
Published:
Abstract
Homogeneous chiral nickel-bisphosphine complexes catalyze the asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides through dynamic kinetic resolution to efficiently afford anti-beta-hydroxy-alpha-amino esters with high diastereo- and enantioselectivities.
Authors
Yasumasa Hamada, Yu Koseki, Takefumi Fujii, Tsukuru Maeda, Takuya Hibino, Kazuishi Makino