Multiple loci on 8q24 associated with prostate cancer susceptibility.
Journal: Nature Genetics
Published:
Abstract
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
Authors
Ali Al Olama, Zsofia Kote Jarai, Graham Giles, Michelle Guy, Jonathan Morrison, Gianluca Severi, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Sameer Jhavar, Ed Saunders, John Hopper, Melissa Southey, Kenneth Muir, Dallas English, David Dearnaley, Audrey Ardern Jones, Amanda Hall, Lynne O'brien, Rosemary Wilkinson, Emma Sawyer, Artitaya Lophatananon, Vincent Khoo, Christopher Parker, Christopher Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin Cooper, Jenny Donovan, Freddie Hamdy, David Neal, Rosalind Eeles, Douglas Easton
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