A case of multiple lymph node metastases from transverse colon cancer successfully treated with oral tegafur/uracil (UFT)/Leucovorin (LV)

Oral tegafur/uracil (UFT)/Leucovorin (LV) therapy has been used for chemotherapy for advanced colorectal cancer with anti-cancer effects the same as conventional 5-fluorouracil and Leucovorin (5-FU/LV). However, the effectiveness and safety of UFT/LV in the treatment of elderly patients with advanced colorectal cancer is not evaluated. We report a case of multiple lymph node metastases from colon cancer successfully treated with UFT/LV. An 81-year-old man had been admitted to our hospital because of left neck and axillary mass, which was diagnosed as transverse colon cancer with multiple lymph node metastases. After a laparoscopic partial resection of transverse colon, UFT/LV (UFT 300 mg/m2/day and LV 75 mg/day) was administered for 4-week-on and 1-week-off. After the administration of the chemotherapy, a good partial response of these metastatic lymph nodes was achieved. No grade 3 or more severe adverse reactions have been observed. He has now survived for 14 months without a recurrence after the administration of the chemotherapy. This case suggests the effectiveness and safety of UFT/LV in elderly patients with colorectal cancer.