Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles.
Journal: Organic Letters
Published:
Abstract
An effective method for the asymmetric synthesis of 3-amino-2-oxindoles was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of N-unprotected 2-oxindoles with azodicarboxylate catalyzed by commercial biscinchona alkaloids in good to excellent yields with high enantioselectivities.
Authors
Liang Cheng, Li Liu, Dong Wang, Yong-jun Chen