Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study.
Journal: Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Published:
Abstract
A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.
Authors
Somnuek Sungkanuparph, Scott Filler, Ploenchan Chetchotisakd, Peter Pappas, Tracy Nolen, Weerawat Manosuthi, Thanomsak Anekthananon, Michele Morris, Khuanchai Supparatpinyo, Heather Kopetskie, Amy Kendrick, Philip Johnson, Jack Sobel, Robert Larsen
Relevant Conditions