Bilateral acute angle-closure glaucoma in a migraine patient receiving topiramate: a case report.

Background: Patients with migraine headaches are frequently prescribed topiramate to treat their condition.

Methods: We present a case of bilateral acute angle-closure glaucoma occurring 2 days after topiramate therapy was increased for symptoms related to migraine.

Conclusions: Acute angle-closure glaucoma secondary to topiramate is an uncommon but serious adverse reaction that may result in severe morbidity such as permanent visual loss if not recognized in a timely manner. Treatment differs from primary acute angle-closure glaucoma in that discontinuation of topiramate is necessary for the glaucoma to resolve.