Relationship between serum homocysteine and other parameters in renal transplant patients.

Background: Hyperhomocysteinemia frequently occurs after renal transplantation. We therefore assessed whether serum homocysteine (Hcy) concentrations were correlated with clinical, paraclinical, and arterial Doppler parameters among renal transplant patients.

Methods: A cross-sectional study was performed on 47 patients (30 males, 17 females) who received unrelated living donor renal transplants.

Results: The mean serum Hcy concentration was 21.7 +/- 8.4 micromol/L (range = 5.8-48 micromol/L); 37 patients (79%) showed hyperhomocysteinemia (Hcy >or= 15 micromol/L). Serum Hcy was strongly related to body mass index (BMI; r = .43, P = .002), cyclosporine trough level (r = .44, P = .005), and serum creatinine concentration (r = .32, P = .028), but not to age, transplant duration, or sex. Multivariate analysis showed that only BMI (P = .003) and cyclosporine trough level (P = .0037) were independent predictors of serum Hcy concentrations. Hyperhomocysteinemia was more prevalent among patients taking mycophenolate mofetil (MMF) than azathioprine (86% vs 50%; P = 0.017). The hyperhomocysteinemia and normohomocysteinemia groups did not differ significantly in mean carotid intima-media thickness (IMT; 0.78 +/- 0.348 vs 0.77 +/- 0.419 mm, P = .97) or mean intrarenal resistive index (RI) (0.7 +/- 0.06 vs 0.7 +/- 0.06, P = .85). The two groups also did not differ in sex prevalence, diabetes, C-reactive protein >or= 5 mg/L, or mean low-density lipoprotein, high-density lipoprotein, and mean arterial pressure (MAP) values.

Conclusions: Serum Hcy correlated with higher cyclosporine trough levels and obesity. Hyperhomocysteinemia was more common among patients taking MMF than azathioprine, but had no effect on intrarenal RI or carotid IMT.