Direct catalytic asymmetric aldol reaction of beta-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex.
Journal: Chemical Communications (Cambridge, England)
Published:
Abstract
A homodinuclear Ni(2)-Schiff base 1 complex (0.1-1 mol%) promoted the direct catalytic asymmetric aldol reaction of beta-keto esters with formaldehyde, giving hydroxymethylated adducts in 94-66% ee.
Authors
Shinsuke Mouri, Zhihua Chen, Shigeki Matsunaga, Masakatsu Shibasaki