Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes.
Journal: Organic Letters
Published:
Abstract
An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.
Authors
Liangguang Wang, Xiaoqiang Yu, Xiujuan Feng, Ming Bao