Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders.
Journal: Journal Of Child And Adolescent Psychopharmacology
Published:
Abstract
Mood symptoms in adult bipolar disorder are associated with increased proinflammatory markers and decreased brain-derived neurotrophic factor (BDNF). We examined serum interleukin-6, high-sensitivity C-reactive protein (hsCRP), and BDNF among 30 bipolar disorder adolescents. Hypomanic/manic symptoms were positively associated with hsCRP. BDNF levels were negatively associated with interleukin-6. Forty percent had cardiovascular high-risk hsCRP levels. Larger longitudinal studies are warranted.
Authors
Benjamin Goldstein, Katelyn Collinger, Francis Lotrich, Anna Marsland, Mary-kay Gill, David Axelson, Boris Birmaher
Relevant Conditions