Lens coloboma and associated ocular malformations.

Objective: Lens coloboma is a rare congenital disorder of crystalline lens characterized by notching of the equator of the lens. Coloboma can occur in isolation or with other ocular malformations. The authors reported 5 cases of lens coloboma associated with some ocular malformations.

Methods: Case reports. The clinical features, imaging findings and associated ocular malformations were reported.

Results: One case was not associated with ocular anomalies. One patient was involved with iris and choroid coloboma; another subject suffered from total cataract; and the fourth patient was affected by lens dislocation. The remaining case included aniridia. The pathogenic mechanisms and relationship of the ocular malformations have been discussed.

Conclusions: Lens coloboma can be associated with other ocular malformations, such as iris coloboma, choroid colobma, localized or total caratact.