Protection effect of Corn Shuang on hyperlipidemic rats vascular wall

Objective: To study the protection of Corn Shuang on hyperlipidemic rats vascular wall and its mechanism of action.

Methods: Thirty Wistar rats were randomly divided into control group, model group and test group (n = 10). Feeding rats according to the experiment requirement, after 15 weeks,the content of lipids, superoxide dismutase (SOD), serum glutathione peroxidase (GSH-Px), malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS) were measured in each group rats serum, morphological changes of rat aortic wall tissue were observed by light microscopy.

Results: The concentration of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and MDA increased significantly in model group (P < 0.01), the concentration of high density lipoprotein (HDL-C), SOD, GSH-Px, NO and NOS decreased significantly (P < 0.01); Corn Shuang could reduce the concentration of TC, TG, LDL-C and MDA in hyperlipidemia rats serum (P < 0.01), promote the content of HDL-C, SOD, GSH-Px, NO and NOS (P < 0.01); Aortic wall showed typical atherosclerotic lesion in model group; Corn shuang could improve significantly damages of artery wall.

Conclusions: Corn Shuang had obvious protective effect on the vessel wall, its mechanism might be related to regulation of blood lipid, antioxidant, maintenance of NO metabolism.