Helicobacter pylori as a part of microbiocenosis of mucosal microflora esophago-gastroduodenal zone in the norm and pathology

AIM; Revealing the level and significance of Helicobacter pylori (H. pylori) in the normobiocenosis and disbacteriosis of mucosal microflora in the osophagogastroduodenal zone.

Methods: Qualitative and quantitative composition of the mucosal microflora was defined in biopsy specimens from different parts of oesophagus, stomach and duodenum in addition to clinical and histological examination in 50 healthy volunteers, 106 ulcer duodenum patients, 24 patients with gastric ulcer, 36 with chronic gastritis and 24 with chronic oesophagitis.

Results: H. pyloril is involved into normomicrobiocenosis of the mocosal microbiota and take part of main defensive function of gastroduodenal tract. Excerbation of peptic ulcer, chronic gastritis and oesophagitis is accompanied with the reduction H. pylori in most cases, though the scar formation occurs both with and without presence of H. pylori.

Conclusions: The colonization of the oesophagogastroduodenal zone by H. pylori has no infection process and play the independent role in the development of the ulcer disease, gastritis and oesophagitis and does not require the eradication.