Characteristics of gastric cancer detected after successful eradication of H. pylori

H. pylori infection plays a important role in gastric carcinogenesis. Japanese randomized controlled study has proved that H. pylori eradication has a preventive effect for the development of gastric cancer. However, gastric cancer is sometimes detected after successful eradication of H. pylori. There is a lack of study about gastric cancers detected after H. pylori eradication. These cancers are reported to have the tendency of smaller size and morphologically higher frequency in depressive type. Also there was feature with a lot of complete gastric type or gastric predominant mixed type immunohistologically. The clinicopathological characteristics of gastric cancers detected after H. pylori eradication were different from those of gastric cancers in patients with H. pylori infection. H. pylori eradication is thought to suppress intestinalization during the development of gastric cancer.