CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis.
Journal: Modern Rheumatology
Published:
Abstract
Objective: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients.
Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism.
Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups.
Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.
Authors
Giulia Pazzola, Luigi Boiardi, Bruno Casali, Enrico Farnetti, Davide Nicoli, Nicolò Pipitone, Ilaria Padovano, Andrea Caruso, Mariagrazia Catanoso, Carlo Salvarani
Relevant Conditions