Combination of incretin-related drugs with other anti-hyperglycemic drugs

Incretin-related drugs(GLP-1 receptor agonists and DPP IV inhibitors) have novel mechanisms for treatment of diabetes and can be combined with other anti-hyperglycemic drugs, such as SU, BG, TZD and alpha-GI drugs to achieve the better control of blood glucose levels. Combination of incretin-related drugs with SU is very effective, as incretin-related drugs and SU can stimulate insulin secretion in a synergistic manner. Combination of DPP IV inhibitors with alpha-GI drugs is also very effective, as alpha-GI drugs increase the secretion of GLP-1 and DPP IV inhibitors decrease the degradation of GLP-1.