PDT panoramic view. Principle, photosensitizers, light sources and validated indications in dermatology

Background: Photodynamic therapy (PDT) combines the use of a topical sensitizer and its excitation with a light of appropriate wavelength. Its use in dermatooncology has been possible in France in 2006 when the methyl ester ALA or Metvixia® got approved.

Objective: To provide a panoramic view of validated indications of PDT in oncodermatology.

Methods: This work is based on the review of the literature as well as available guidelines or recommendation on PDT in dermatology.

Results: Standardized protocols and results of the main clinical trials are given for the three major indications in dermatology: actinic keratosis, basal cell carcinoma and Bowen disease.

Conclusions: PDT has its role to play in the treatment of multiple superficial carcinomas and cutaneous precancerous lesions and its main advantage resides in its optimal healing.