Cord ghrelin levels are decreased in large-for-gestational-age neonates.

Ghrelin is a growth hormone secretagogue peptide and has been recognized as an orexigenic factor. To investigate relationship between cord ghrelin and anthropometric and metabolic indices, we measured cord ghrelin in large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) neonates and examined whether cord ghrelin levels were correlated to concentrations of cord blood glucose, insulin, lipid and maternal ghrelin. Fifty-five singletons born at term and their mothers were investigated in this study. Maternal venous blood samples were collected before delivery. Plasma concentrations of ghrelin, insulin, glucose, total cholesterol, triacylglycerol (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol were measured in cord blood sampled at birth. The results show that the concentrations of cord ghrelin are significantly lower in LGA neonates. There is a positive correlation between cord ghrelin levels and maternal ghrelin levels. Negative correlations are found between cord ghrelin levels and gestational age, the concentrations of cord glucose, insulin, TG and LDL. Multivariate regression analyses show that birth weight (r(2)  = 0.674, β = -0.548, P < 0.001) was the predictor correlating with ghrelin levels. In conclusion, LGA neonates have lower cord ghrelin concentrations than AGA neonates.