The extract of Zataria multiflora affect tracheal responsiveness, serum levels of NO, nitrite, PLA2, TP and histamine in sensitized Guinea pigs.

Background: Different therapeutic effects for Zataria multiflora have been described in Iranian traditional medicine. In addition anti-inflammatory and anti-oxidant effects of this plant were previously described. The effect of the extract of Zataria multiflora on tracheal responsiveness (TR) and inflammatory mediators of sensitized guinea pigs was examined.

Methods: Five groups of sensitized guinea pigs to ovalbumin (OA) were given drinking water alone, drinking water containing three concentrations of the extract and dexamethasone. TR to methacholine and OA, serum levels of NO, nitrite, PLA2, TP and histamine were measured (n=6, for each groups).

Results: TR to methacholine and OA, serum levels of NO, nitrite, PLA2, TP and histamine were increased in sensitized animals compared to control group (p<0.05 to p<0.001). Treatment of sensitized animals with dexamethasone and most concentration of the extract lead to significantly decrease in all measured parameters compared to sensitized group (p<0.05 to p<0.001) except TP and histamine levels in treated group with dexamethasone.

Conclusions: These results showed a preventive effect of the extract of Zataria multiflora on tracheal responsiveness, serum level of NO, nitrite, total protein, PLA2 and histamine in sensitized guinea pigs which was equal or even more potent than dexamethasone at used concentrations.