Comparison of hepatocellular carcinoma with cirrhosis patients undergoing hepatic resection between hepatitis B and C infection.

Objective: Type B and C hepatic cirrhosis are main causes of hepatocellular carcinoma (HCC). In resected cases of HCC, residual liver function of type B cirrhotic patients tend to be better compared to type C cirrhotic patients. We compared clinical data of patients with type B hepatic cirrhosis with type C hepatic cirrhosis who underwent hepatic resection for HCC.

Methods: Subjects were 16 patients with type B hepatic cirrhosis and 20 patients with type C hepatic cirrhosis who underwent hepatic resection for HCC at Jikei University Hospital. Perioperative findings including age, gender, preoperative laboratory data including ICGR15, Child's classification, model for end-stage liver disease (MELD) score, tumor factor, type of resection, duration of operation, blood loss and incidence of post-operative complications, as well as disease-free and overall survival were analyzed.

Results: In type B cirrhotic patients, the age was younger (p<0.001), pre-operative ICGR15 (p=0.004), hemoglobin (p=0.032), albumin (p=0.006), Child's classification (p=0.008), and MELD score (p=0.011) were better, and incidence of postoperative pulmonary complications were fewer (p=0.039) than type C cirrhotic patients. Preoperative ICG, in 11 of 16 type B cirrhotic patients were normal (<10%).

Conclusions: Residual liver function of type B cirrhotic patients were better than type C cirrhotic patients.