Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)-H bonds with aryl halides using a removable auxiliary.
Journal: Chemical Communications (Cambridge, England)
Published:
Abstract
A Pd(II)-catalyzed arylation of methylene C(sp(3))-H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.
Authors
Qi Zhang, Xue-song Yin, Sheng Zhao, Sheng-long Fang, Bing-feng Shi