Three-component reaction of small-ring cyclic amines with arynes and acetonitrile.
Journal: Chemical Communications (Cambridge, England)
Published:
Abstract
A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl γ-aminobutyronitriles and δ-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.
Authors
David Stephens, Yu Zhang, Mathew Cormier, Gabriel Chavez, Hadi Arman, Oleg Larionov