Cyclosporine treatment of angioimmunoblastic T-cell lymphoma relapsed after an autologous hematopoietic stem cell transplant.

An angioimmunoblastic T-cell lymphoma is a unique type of peripheral T-cell lymphoma; it has an aggressive course and a poor prognosis. There is no standard therapy for angioimmunoblastic T-cell lymphoma, especially for refractory or relapsed cases. Here, we report a case of 53-year-old woman with angioimmunoblastic T-cell lymphoma who underwent high-dose chemotherapy with an autologous hematopoietic stem cell transplant after several cycles of chemotherapy, but soon relapsed with severe autoimmune hemolytic anemia. The patient was given dexamethasone and thalidomide, but responded poorly; however, she responded well to cyclosporine and finally achieved a sustained response. Thus, we conclude that cyclosporine has an effect in relapsed angioimmunoblastic T-cell lymphoma after an autologous hematopoietic stem cell transplant.