Optimal composition of dialysis fluid for on-line hemodiafiltration in central dialysis fluid delivery system.

In this paper, we propose 'the preferred composition of dialysis fluid for on-line hemodiafiltration (HDF) in central dialysis fluid delivery system, (CDDS)': sodium concentration 138-140 mEq/l; potassium concentration 2.0 mEq/l; calcium concentration 2.5-3.5 mEq/l; glucose concentration 1.0-1.5 g/l; buffer: bicarbonate (acetate free is preferred). Concentrations of electrolytes in dialysis fluid (= substitution fluid) are applied to the compositions of launched dialysis fluid in Japan. From the viewpoint of biocompatibility and correction of metabolic acidosis, acetate-free bicarbonate buffer is thought to be important. This proposal of the preferred composition of dialysis fluid for on-line HDF in CDDS is based on a few reports. Further investigations and research to reveal the optimal composition of dialysis fluid for on-line HDF are expected in the future.