A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Journal: Nature Genetics
Published:
Abstract

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Authors
Ali Al Olama, Zsofia Kote Jarai, Sonja Berndt, David Conti, Fredrick Schumacher, Ying Han, Sara Benlloch, Dennis Hazelett, Zhaoming Wang, Ed Saunders, Daniel Leongamornlert, Sara Lindstrom, Sara Jugurnauth Little, Tokhir Dadaev, Malgorzata Tymrakiewicz, Daniel Stram, Kristin Rand, Peggy Wan, Alex Stram, Xin Sheng, Loreall Pooler, Karen Park, Lucy Xia, Jonathan Tyrer, Laurence Kolonel, Loic Le Marchand, Robert Hoover, Mitchell Machiela, Merideth Yeager, Laurie Burdette, Charles Chung, Amy Hutchinson, Kai Yu, Chee Goh, Mahbubl Ahmed, Koveela Govindasami, Michelle Guy, Teuvo L Tammela, Anssi Auvinen, Tiina Wahlfors, Johanna Schleutker, Tapio Visakorpi, Katri Leinonen, Jianfeng Xu, Markus Aly, Jenny Donovan, Ruth Travis, Tim Key, Afshan Siddiq, Federico Canzian, Kay-tee Khaw, Atsushi Takahashi, Michiaki Kubo, Paul Pharoah, Nora Pashayan, Maren Weischer, Borge Nordestgaard, Sune Nielsen, Peter Klarskov, Martin Røder, Peter Iversen, Stephen Thibodeau, Shannon Mcdonnell, Daniel Schaid, Janet Stanford, Suzanne Kolb, Sarah Holt, Beatrice Knudsen, Antonio Coll, Susan Gapstur, W Diver, Victoria Stevens, Christiane Maier, Manuel Luedeke, Kathleen Herkommer, Antje Rinckleb, Sara Strom, Curtis Pettaway, Edward Yeboah, Yao Tettey, Richard Biritwum, Andrew Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Anand Chokkalingam, Lisa Cannon Albright, Cezary Cybulski, Dominika Wokołorczyk, Wojciech Kluźniak, Jong Park, Thomas Sellers, Hui-yi Lin, William Isaacs, Alan Partin, Hermann Brenner, Aida Dieffenbach, Christa Stegmaier, Constance Chen, Edward Giovannucci, Jing Ma, Meir Stampfer, Kathryn Penney, Lorelei Mucci, Esther John, Sue Ingles, Rick Kittles, Adam Murphy, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, William Blot, Lisa Signorello, Wei Zheng, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Barbara Nemesure, John Carpten, Cristina Leske, Suh-yuh Wu, Anselm Hennis, Adam Kibel, Benjamin Rybicki, Christine Neslund Dudas, Ann Hsing, Lisa Chu, Phyllis Goodman, Eric Klein, S Zheng, Jyotsna Batra, Judith Clements, Amanda Spurdle, Manuel Teixeira, Paula Paulo, Sofia Maia, Chavdar Slavov, Radka Kaneva, Vanio Mitev, John Witte, Graham Casey, Elizabeth Gillanders, Daniella Seminara, Elio Riboli, Freddie Hamdy, Gerhard Coetzee, Qiyuan Li, Matthew Freedman, David Hunter, Kenneth Muir, Henrik Gronberg, David Neal, Melissa Southey, Graham Giles, Gianluca Severi, Stephen Chanock, Brian Henderson, Douglas Easton, Rosalind Eeles, Christopher Haiman
Relevant Conditions

Prostate Cancer