Clinical value of quantitative measurements derived from GATED SPECT: motion and thickening, volumes and related LVEF.

Radionuclide myocardial perfusion imaging using ECG-gated acquisition with single photon emission computed tomography (gated SPECT) is the current state of the art imaging modality for symptomatic patients with known or at least indeterminate likelihood of coronary artery disease. Gated SPECT provides a wide variety of additional information about left ventricular (LV) function measurements, for example LV volumes, ejection fraction (LVEF) and regional wall motion abnormalities. This contributes to a higher diagnostic accuracy, additional prognostic information and predicting benefit from revascularization in these patients. Gated SPECT is an easily reproducible and accurate tool, which provides additional information to myocardial perfusion, regarding functional LV data. Assessment of LV wall motion, volumes and LVEF increases diagnostic accuracy and has prognostic and predictive value for the individual patient.