Association between Subclinical Atherosclerosis among Hyperlipidemia and Healthy Subjects.

Background: The global burden ofcardiovascular disease (CVD) continues to rise as developing nations. Primary prevention is effective in populations traditionally considered low-risk. Carotid intima-media thickness (CIMT) is considered as a surrogate marker for CVD.

Objective: Correlation between surrogate markers of subclinical atherosclerosis CIMT, carotid plaque and CVD risk factors in hyperlipidemia and healthy group.

Methods: Cross sectional study, aged 18-80 years from cardiovascular clinic, Suranaree University of Technology Hospital and measurement CIMT Correlates between CIMT and traditional CVD risk factors age, gender; body mass index (BMI), Waist hip ratio (WHR), total cholesterol, triglyceride, HDL-cholesterol level, LDL-cholesterol level were assessed in the entire population.

Results: Population 302 subjects (male 154 [51%]), mean age 47.17 ± 10.95 years were found to be hyperlipidemia 216 (71.5%) and healthy 86 (28.5%) subjects. Comparability between hyperlipidemia and healthy subject not different in BMI, WHR, and FBS. Mean left and right CIMT no difference between hyperlipidemia and healthy subjects. CIMT correlated with hyperlipidemia higher LDL-cholesterol level (r = 0.12, p = 0.03), triglyceride (r = 0.18 p < 0.01), WHR (r = 0.19, p < 0.01) and SBP (r = 0.2 2, p < 0.01). The correlation coefficients were not significantly different between CIMT and traditional risk factors age, gender; BMI, LDL-C and HDL-C.

Conclusions: The subclinical atherosclerosis CIMTvalues are closely associated with hyperlipidemia along with cholesterol, triglyceride, WHR and SBP.