Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst.
Journal: Chemical & Pharmaceutical Bulletin
Published:
Abstract
Diaminomethylenemalononitrile organocatalysts promote the asymmetric chlorination of simple cyclic β-keto esters such as methyl, ethyl, and benzyl esters of 1-oxo-2,3-dihydro-1H-indene-2-carboxylic acid. This affords the corresponding chiral α-chlorinated carbonyl products in excellent yields with high enantioselectivities.
Authors
Takaaki Sakai, Shin-ichi Hirashima, Kosuke Nakashima, Chie Maeda, Akihiro Yoshida, Yuji Koseki, Tsuyoshi Miura