Efficacy of plasmapheresis for the treatment of pure red blood cell aplasia after allogeneic stem cell transplantation.
Journal: Transfusion
Published:
Abstract
Background: Pure red blood cell aplasia (PRCA) is a complication of ABO major-incompatible stem cell transplantation, likely due to the persistence of memory B lymphocytes of recipient origin, which produce hemagglutinins against ABO antigens on donor RBCs. At present no standard of care is established for this complication.
Methods: We report a case of PRCA after allogeneic bone marrow transplantation, successfully treated with plasma exchange (PEX) after failing erythropoietin administration.
Results: The patient fully recovered from RBC aplasia.
Conclusions: This case suggests a role for PEX in the treatment of PRCA after allogeneic stem cell transplantation.
Authors
Chiara Dellacasa, Stefano D'ardia, Bernardino Allione, Semra Aydin, Valter Tassi, Tiziana Francisci, Clara Pecoraro, Alessandro Busca
Relevant Conditions