Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction.
Journal: Organic Letters
Published:
Abstract
A Michael-aldol reaction of 2-mercaptobenzaldehyde with β-indole-β-CF3 enones catalyzed by a squaramide has been realized. The method affords a series of 2-CF3-2-indole-substituted thiochromanes featuring a CF3-containing quaternary stereocenter in excellent yields, diastereoselectivities, and enantioselectivities.
Authors
Yuanyuan Zhu, Zhenghao Dong, Xin Cheng, Xiaoling Zhong, Xiaolin Liu, Li Lin, Zhiqiang Shen, Peiju Yang, Yuan Li, Hailin Wang, Wenjin Yan, Kairong Wang, Rui Wang