Inhibitory activity of avibactam against selected β-lactamases expressed in an isogenic Escherichia coli strain.
Journal: Diagnostic Microbiology And Infectious Disease
Published:
Abstract
Avibactam restored the in-vitro antibacterial activity of ceftazidime, ceftaroline, and aztreonam against isogenic Escherichia coli expressing class A, class C, and class D β-lactamases. The enzymes included TEM and CTX-M extended spectrum β-lactamases, ACT, CMY and FOX AmpC-type enzymes, and carbapenemases including rarer KPC variants and OXA-139.
Authors
Tommaso Giani, Antonio Cannatelli, Vincenzo Di Pilato, Raymond Testa, Wright Nichols, Gian Rossolini