Diagnosis of Zika virus infection on a nanotechnology platform.
Journal: Nature Medicine
Published:
Abstract
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.
Authors
Bo Zhang, Benjamin Pinsky, Jeyarama Ananta, Su Zhao, Shylaja Arulkumar, Hao Wan, Malaya Sahoo, Janaki Abeynayake, Jesse Waggoner, Clay Hopes, Meijie Tang, Hongjie Dai
Relevant Conditions