Research on the effect of RNA interference on mast cells in respiratory allergic diseases

Respiratory allergic disease has become a major health problem in the 21st century.Mast cells are key effector cells of the respiratory anaphylaxis, and can form a variety of features of allergic inflammation by producting large numbers of inflammatory mediators.RNAi can affect the disease process by silencing gene expression, and has made significant process in the study of many diseases, but the research of targeting mast cells for the treatment of respiratory allergic diseases is rare.This review focuses on recent advances of the application of RNA interference on mast cell in respiratory allergic diseases, aming to further understand its application in the respiratory allergic diseases and research status, and broaden new ideas of treating respiratory allergies.