A review on group 2 innate lymphoid cells in airway inflammation

Inflammatory airway diseases, including allergic rhinitis and asthma, are type 2 immune responses induced by antigen presenting cells and T helper cells, resulting as a consequence of great recruitment of effect cells and release of cytokines. Group 2 innate lymphoid cells were originally described as a novel population of lineage negative cells and play an important role in the onset and progression of airway inflammation by producing the critical Th2-type cytokines IL-5 and IL-13 in response to epithelial cell derived IL-25, IL-33 and thymic stromal lymphopoietin. Along with a better understanding of regulatory and effect mechanism, targeting ILC2s could be a potential therapeutic approach in inflammatory airway diseases.