NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.
Journal: Multiple Sclerosis (Houndmills, Basingstoke, England)
Published:
Abstract
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
Authors
Sunny Malhotra, Melissa Sorosina, Jordi Río, Silvia Peroni, Luciana Midaglia, Luisa Villar, José Álvarez Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe Zettl, Jeannette Lechner Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi, Xavier Montalban, Filippo Martinelli Boneschi, Manuel Comabella
Relevant Conditions