Amidyl Radical Directed Remote Allylation of Unactivated sp3 C-H Bonds by Organic Photoredox Catalysis.

The development of visible-light-mediated allylation of unactivated sp3 C-H bonds is reported. The remote allylation was directed by the amidyl radical, which was generated by photocatalytic fragmentation of a pre-functionalized amide precursor. Both aromatic and aliphatic amide derivatives could successfully deliver the remote C-H allylation products in good yields. A variety of electron deficient allyl sulfone systems could be used as δ-carbon radical acceptor.