Intracranial plasma cell granuloma : a report of four cases.

Intracranial plasma cell granulomas are a rare group of idiopathic inflammatory pseudotumours often mistaken for lymphoreticular malignancies and myeloproliferative disorders. The clinial and pathological findings in respect of four cases of intracranial plasma cell granuloma clinically diagnosed as meningioma and glioma are presented in this report. The range of microscopic features seen included a mixed cell population with predominance of plasma cells, absence of cellular atypia and mitosis, multinucleate giant cells, perivascular cuffing by inflammatory cells and emperipolesis. The major considerations in differential diagnosis of this lesion are discussed.