Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.

Journal: Alzheimer's & Dementia (Amsterdam, Netherlands)

Published: November 13, 2018

Abstract

Background: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET.

Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history.

Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity.

Conclusions: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

Authors

Nelly Joseph Mathurin, Yi Su, Tyler Blazey, Mateusz Jasielec, Andrei Vlassenko, Karl Friedrichsen, Brian Gordon, Russ Hornbeck, Lisa Cash, Beau Ances, Thomas Veale, David Cash, Adam Brickman, Virginia Buckles, Nigel Cairns, Carlos Cruchaga, Alison Goate, Clifford Jack, Celeste Karch, William Klunk, Robert Koeppe, Daniel Marcus, Richard Mayeux, Eric Mcdade, James Noble, John Ringman, Andrew Saykin, Paul Thompson, Chengjie Xiong, John Morris, Randall Bateman, Tammie L Benzinger

Relevant Conditions

Alzheimer's Disease, Dementia

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.

Similar Publications