A combination of 2940-nm laser and photodynamic therapy for treatment of recalcitrant facial flat warts.

Background: Photodynamic therapy (PDT) is one of the treatment options for generalized facial flat warts, which results in elimination of virus and inhibition of proliferation of warts due to photochemical and phototoxic reactions. In this research, we attempted to evaluate the efficacy and safety profiles of a combination of 2940-nm laser and PDT for the treatment of generalized recalcitrant facial flat warts.

Methods: Retrospective analysis of the patients with recalcitrant facial warts was performed. Patients in the combined group (n = 40) were treated with a 2940-nm single spot abrasion followed by a PDT; while the PDT group (n = 40) received a PDT treatment only. The efficacy was assessed by the lesion numbers and lesion clearance rate. The effective rate was calculated with the cured and excellent response rates.

Results: The combined group showed significant improvements in the total effective rate (77.5%vs. 57.5%, p = 0.0416) and average clearance rate (81.68±2.83% vs. 68.13 ± 3.97%, p = 0.0068) as compared with the PDT-only group. The degree of lesion clearance was positively correlated with the treatment times in both groups. After three months of follow-up, no relapse occurred in patients from either group. Furthermore, an accumulation of photosensitizer in the lesional areas was observed in the combined treatment group.

Conclusions: A combination of 2940-nm laser and PDT was safe and showed significantly more effect than PDT alone in treatment for recalcitrant facial flat warts, partially due to the improved uptake of photosensitizer after 2940-nm laser induced skin abrasion.