Cause-specific death assessment of patients with stage I small-cell lung cancer: a competing risk analysis.

Journal: Future Oncology (London, England)
Published:
Abstract

Aim: Stage I small-cell lung cancer (SCLC) is a potentially curable disease that needs timely and multidisciplinary management. The aim of this study was to evaluate the probability of cause-specific mortality for patients with stage I SCLC. Material &

Methods: We identified patients in the SEER database and constructed a proportional subdistribution hazard model to evaluate cancer-specific mortality. A nomogram was built based on Fine and Gray competing risk regression model.

Results:  A total of 864 stage I SCLC patients were identified. The 5-year cumulative incidence of SCLC-specific mortality was 56.2%, while that for other causes of death was 17.3%. The c-index for the prognostic prediction model was 0.66. Besides, the nomogram was well calibrated.

Conclusion: Our nomogram might serve as a reference for clinicians when evaluating the prognosis of stage I SCLC.

Authors
Jiaqing Liu, Huaqiang Zhou, Yaxiong Zhang, Wenfeng Fang, Yunpeng Yang, Shaodong Hong, Gang Chen, Shen Zhao, Xi Chen, Zhonghan Zhang, Wei Xian, Jiayi Shen, Yan Huang, Hongyun Zhao, Li Zhang